Symptoms of pHLH in adolescents Symptoms of pHLH in infants Symptoms of pHLH in adults Symptoms of pHLH in adolescents
Scared woman in the woods. Names of symptoms are floating in the fog behind her (fever, cytopenias, hepatosplenomegaly, inflammatory CNS symptoms, hyperferritinemia) Infant sitting down in the woods, looking scared. Names of symptoms floating in fog behind him (fever, cytopenias, hepatosplenomegaly, inflammatory CNS symptoms, hyperferritinemia) Scared man in the woods looking lost. Names of symptoms floating in fog behind him (fever, cytopenias, hepatosplenomegaly, inflammatory CNS symptoms, hyperferritinemia) Scared woman in the woods. Names of symptoms are floating in the fog behind her (fever, cytopenias, hepatosplenomegaly, inflammatory CNS symptoms, hyperferritinemia)

Suspect pHLH before
another person is lost

Know the initial signs of primary hemophagocytic lymphohistiocytosis (pHLH). It could save a life 1

Discover the deadliest disease
you've never diagnosed 2,3

Learn more

Suspect your patient
may have pHLH?

Know the signs

pHLH can be treated
when diagnosed early 4

Find out how

References: 1. Henter JI, Horne A, Aricò M, et al. HLH-2004: diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis. Pediatr Blood Cancer . 2007;48(2):124-131. doi:10.1002/pbc.21039 2. Esteban YM, de Jong JLO, Tesher MS. An overview of hemophagocytic lymphohistiocytosis. Pediatr Ann . 2017;46(8):e309-e313. doi:10.3928/19382359-20170717-01 3. Vizcaino MA, Eberhart CG, Rodriguez FJ. Hemophagocytic lymphohistiocytosis in adults with intraocular involvement: clinicopathologic features of 3 cases. Ocul Oncol Pathol . 2017;4(1):1-11. doi:10.1159/000475551 4. Bergsten E, Horne A, Myrberg IH, et al. Stem cell transplantation for children with hemophagocytic lymphohistiocytosis: results from the HLH-2004 study. Blood . 2020;4(15):3754-3766. doi:10.1182bloodadvances.2020002101

Dark, wooded forest with fog
Dark, wooded forest with fog
Dark, wooded forest with fog
Dark, wooded forest with fog
Dark, wooded forest with fog
cheveron down References

References: 1. Henter JI, Horne A, Aricò M, et al. HLH-2004: diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis. Pediatr Blood Cancer . 2007;48(2):124-131. doi:10.1002/pbc.21039 2. Esteban YM, de Jong JLO, Tesher MS. An overview of hemophagocytic lymphohistiocytosis. Pediatr Ann . 2017;46(8):e309-e313. doi:10.3928/19382359-20170717-01 3. Vizcaino MA, Eberhart CG, Rodriguez FJ. Hemophagocytic lymphohistiocytosis in adults with intraocular involvement: clinicopathologic features of 3 cases. Ocul Oncol Pathol . 2017;4(1):1-11. doi:10.1159/000475551 4. Bergsten E, Horne A, Myrberg IH, et al. Stem cell transplantation for children with hemophagocytic lymphohistiocytosis: results from the HLH-2004 study. Blood . 2020;4(15):3754-3766. doi:10.1182bloodadvances.2020002101